* Methoxyflurane has been used by ambulance services in Australia, the Middle East, parts of Asia and Europe for many years.

Methoxyflurane is a volatile liquid used as an inhaled analgesic. It has a rapid onset and a very short duration of action with minimal side effects

Mechanism of Action!

Methoxyflurane (2,2-dichloro-1,1-difluoro-1-methoxyethane) is part of a family of halogenated hydrocarbon anaesthetic agents. 


Fun fact: It’s the only one in the group that provides analgesia at sub-anaesthetic doses and nobody knows why!

Actually, the mechanism of action is not well understood. Penthrox appears to reduce pain by interfering with GABA, glycine and glutamate receptors.

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